团队负责人
张宏亮 理学博士，副教授，硕士生导师
疾病免疫与干预研究中心副主任
系统医学研究中心副主任（主持工作）
所在学系：基础医学系
研究方向：免疫炎症的机制研究，主要研究痛风、类风湿关节炎和骨关 节炎等炎症性关节疾病
电子邮箱：tmv@mail.ustc.edu.cn
团队成员
金腾川、吴松泉、张宏亮、任丹、朱泽悦、俞镇楠、陈静芹、叶晓鸥、陈瑞明
研究方向
团队聚焦炎症和肿瘤两大疾病，炎症方向主要研究痛风、类风湿关节炎和骨关节炎等炎症性关节疾病，肿瘤方向聚焦于口腔和消化系统肿瘤，团队围绕两大方向开展机制研究，发现新的治疗靶点，基于纳米抗体开发和中药小分子筛选进行疾病干预手段研发。
团队主持科研项目
1. 国家自然科学基金委员会，青年项目，m/sPD-L1调控NLRP3炎症小体活化的分子机制研究及其在急性和慢性痛风转化中的作用，2025-01-01至2027-12-31。
2. 国家自然科学基金委员会，青年项目，基于LDHA乳酰化-嘧啶代谢轴探讨禹州漏芦有效成分Ter重塑肺腺癌免疫微环境作用机制研究，2027-01-01至2029-12-31。
3. 浙江省自然科学基金委员会，青年项目, MSU调控时钟基因表达影响痛风发作的昼夜节律调控机制研究，2025-01-01至2026-12-31。
4. 浙江省教育厅，禹州漏芦活性成分Ter调控代谢重编程抗肺癌作用研究，2025-10-01至2027-09-30。
5. 丽水学院，医校联合开放基金，CSF1R激酶在痛风中的功能探究，2025-01-01至2026-12-31。
发表论著和专著(*, 通讯作者; #, 第一作者)
2026
1. Zhang H#, Jin T, Xue M, Wu S, Zheng C (2026). When glycobiology meets inflammasome activation: Insights and implications. J Adv Res. S2090-1232(25)00214-0.
2. Zhang H#, Chen Q#, Yu H, Zhu M, Zhang X, Fu X, Wu S and Wang G (2026) Role of IL-32 in RA pathology and potential as a drug target. Front. Immunol. 17:1696081.
3. Jingqin Chen; Qiuyin Huang; Congyan Hou; Jiao Liang; Jieying Guan; Sirou Chen; Xinyuan Wang; Ren Zhang; Yanli He，Lycium barbarum polysaccharide suppresses uridine induced malignant progression of lung adenocarcinoma via UPP1 regulation，Cell Investigation，2026，2(1)：100045
4. PengYu Zhang; JiaYing Bao; ChenYu Yuan; Hyun-Jin Kim; Hee Soon Shin; Zhen Nan Yu*; Ok Hee Chai*; Laminaria japonica extract alleviates fine particulate matter-exacerbated allergic rhinitis by inhibiting NLRP3-mediated pyroptosis and restoring epithelial barrier function, Phytomedicine, 2026, 150: 157620
2025
1. Zhang, H#., Tan, B., Tang, T., Tao, J., Jin, T., & Wu, S. (2025). Targeting inflammasomes as a therapeutic potential for HIV/AIDS. Cellular and molecular life sciences : CMLS, 82(1), 162.
2. Ren D, Ye X, Chen R, Jia X, He X, Tao J, Jin T, Wu S, Zhang H* (2025). Activation and evasion of inflammasomes during viral and microbial infection. Cell Mol Life Sci. 82(1):56.
3. Ye, X., Ren, D., Chen, Q., Shen, J., Wang, B., Wu, S., & Zhang, H*. (2025). Resolution of inflammation during rheumatoid arthritis. Frontiers in cell and developmental biology, 13, 1556359.
4. 陈静芹; 侯聪艳; 江章瑜; 李东阳; 许俊诺; 金贺; 王馨苑; 张韧; 何彦丽，基于嘧啶代谢基因构建肺腺癌预后模型及其免疫特征分析，中国临床药理学杂志，2025，41(12)：1762-1767
5. Yu, Zhen Nan; Fan, Yan Jing; Van Nguyen, Thi; Piao, Chun Hua; Lee, Byung-Hoo; Lee, So Young; Shin, Hee Soon; Kim, Tae-Geum; Song, Chang Ho; Chai, Ok Hee*; Undaria pinnatifida extract attenuates combined allergic rhinitis and asthma syndrome by the modulation of epithelial cell dysfunction and oxidative stress, Acta Biochimica Et Biophysica Sinica, 2025, 57(5): 792- 804
6. Masoumeh Ghorbani; Danial Kahrizi; Elham Arkan; Zhennan Yu*; Preparation and characterization of immobilized indole−3−butyric acid on silver−cerium oxide nanoparticles for improving its stability and utilization in the study of plant root formation indices, Frontiers in Plant Science, 2025, 16: 1-14
7. Dan Ren, Current Situation of Goose Astrovirus in China: A Review. Viruses, 2025/1/10.
2024
1. Zeyue Zhu，Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors and is Required for Placenta Morphogenesis and Vasculature Formation. Advanced Science, 2024/06/25.
2. Yu, Zhen Nan; Fan, Yan Jing; Nguyen, Thi Van; Piao, Chun Hua; Lee, Byung-Hoo; Lee, So Young; Shin, Hee Soon; Song, Chang Ho; Chai, Ok Hee*; Undaria pinnatifida ameliorates nasal inflammation by inhibiting eosinophil and mast cell activation and modulating the NF-κB/MAPKs signaling pathway, IMMUNITY INFLAMMATION AND DISEASE, 2024, 12(3)
2022
1. Dan Ren, A peptide-based ELISA for detection of antibodies against novel goose astrovirus type 1. Journal of Virological Methods, 2022/11/7.
2021
1. Dan Ren, Identification of three novel B cell epitopes in ORF2 protein of the emerging goose astrovirus and their application. Applied Microbiology and Biotechnology, 2021/12/18.
本科生培养
1. 第十三届浙江省大学生医学技术技能大赛基础医学赛道铜奖，2023。
2. 第十四届浙江省大学生医学技术技能大赛基础医学赛道铜奖，2024。
3. 第十五届浙江省大学生医学技术技能大赛基础医学赛道银奖，2025。