一、科研简况及代表性成果 （一）学术兼职 国家自然基金评委，广东省科学基金省外评委，美国血液学学会会员，丽水学院医学院炎症相关疾病研究所所长，丽水学院学术带头人 （二）近年主持科研项目 主持国家自然科学基金，面上项目， C/EBPα靶基因和Cebpa增强子表观遗传修饰与急性髓系白血病相关性的研究 ，经费55
（三）主要论文和著作 Guo H,* Barberi T,* and Friedman AD Progression of B Lymphopoiesis Past the PreproB Stage Requires C/EBPThe Journal of Immuology, 2018 Sep 15;201(6):1692-1704. doi: 10.4049/jimmunol.1800244. Epub 2018 Jul 30 Guo H, Cooper S, Friedman AD. In Vivo Deletion of the Cebpa +37 kb Enhancer Markedly Reduces Cebpa mRNA in Myeloid Progenitors but Not in Non-Hematopoietic Tissues to Impair Granulopoiesis. PLoS One. 2016 Mar 3;11(3): e0150809. Leong WY, Guo H, Ma O, Huang H, Cantor AB, Friedman AD Runx1 Phosphorylation by Src Increases Trans-activation via Augmented Stability, Reduced Histone Deacetylase (HDAC) Binding, and Increased DNA Affinity, and Activated Runx1 Favors Granulopoiesis The Journal of Biological Chemistry 2016 Jan 8;291(2):826-36 Cooper S, Guo H, Friedman AD The +37 kb Cebpa Enhancer Is Critical for Cebpa Myeloid Gene Expression and Contains Functional Sites that Bind SCL, GATA2, C/EBPα, PU.1, and Additional Ets Factors. PLoS One. 2015 May 4;10(5): e0126385. Guo H, Ma O, Friedman AD The Cebpa +37 kb enhancer directs transgene expression to myeloid progenitors and to long-term hematopoietic stem cells Journal Leukocyte Biology 2014 Sep;96(3):419-26. Guo H, Ma O, Speck NA, Friedman AD. Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis.Blood. 2012 May 10; 119(19):4408-18. Guo H, Friedman AD Phosphorylation of RUNX1 by cyclin-dependent kinase reduces direct interaction with HDAC1 and HDAC3The Journal of Biological Chemistry 2011 Jan 7; 286(1):208-15. Wang P, Lin C, Smith ER, Guo H, Sanderson BW, Wu M, Gogol M, Alexander T, Seidel C, Wiedemann LM, Ge K, Krumlauf R, Shilatifard A. Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II Molecular Cellular Biology2009 Nov;29(22):6074-85 Zhang L, Fried FB, Guo H, Friedman AD. Cyclin dependent kinase phosphorylation of RUNX1/AML1 on 3 sites increases transactivation potency and stimulates cell proliferation Blood 2008 Feb 1; 111(3): 1193-200. Guo H, Fang B, Liao L, Zhao Z, Liu J, Chen H, Hsu SH, Cui Q, Zhao RC. Haemangioblast Characteristics of Fetal Bone Marrow-derived Flk1+ CD31-CD34 – Cell Experimental Hematology 2003 Jul; 31(7):650-83
二、指导研究生简况 从事多名博士生和博士后的实验指导和培训工作（美国约翰霍普金斯大学） 三、研究领域 主要研究方向为转录因子在造血和白血病转录调控及白血病分子生物学机制的研究，以及炎症与肿瘤的相关性的研究 |
